The Southern Cross is a constellation visible from the Southern hemisphere.
As an aircraft name, Southern Cross may be:
Individual aircraft:
- (as Croix du Sud) Latécoère 300 c/n 1 operated by Aéropostale
- Fokker F.VII c/n 4909 flown by Sir Charles Kingsford Smith across the Pacific Ocean
- Boeing 377 c/n 15930 operated by Pan Am as Clipper Southern Cross